CYP2C9 Index Natura structuraque biochemica | Genetica | Pharmaca ad CYP2C9 relata | Notae | Nexus externi | Tabula navigationis"Structure and dynamics of the membrane-bound cytochrome P450 2C9""Membrane position of ibuprofen agrees with suggested access path entrance to cytochrome P450 2C9 active site"

Cytochromata P450


-atis, n.Numerus ECcytochromatum P450polypeptidumacidis aminicisgenichromosomate 10







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Cytochroma P450 CYP2C9.


Cytochroma P450 CYP2C9 (-atis, n.) (Numerus EC: 1.14.13.48) est haemoproteinum et pars gregis cytochromatum P450.




Index





  • 1 Natura structuraque biochemica


  • 2 Genetica


  • 3 Pharmaca ad CYP2C9 relata


  • 4 Notae


  • 5 Nexus externi




Natura structuraque biochemica |


Cytochroma P450 CYP2C9 est et polypeptidum et haemoproteinum, quod ex 490 acidis aminicis (massa 55.628 Da) constitutum est. Intra cellulam enzymum hoc in ancoris membranae stat[1].



Genetica |


Nomen geni cytochromatis est CYP2C9 locus cuius geneticus in chromosomate 10 humano locatus est (10q23.33).



Pharmaca ad CYP2C9 relata |










Pharmaca relata ad CYP2C9[2][3].

SubstratiInhibitores[4]Inductores[5]

  • Analgetica
    • Celecoxibum

    • Diclofenac


    • Ibuprofenum[6]

    • Naproxenum


  • Antidepressiva
    • Amitriptylinum

    • Fluoxetinum



  • Inhibitor receptorii angiotensini II
    • Candesartanum

    • Irbesartanum

    • Losartanum



  • Sulphonylureae
    • primae generationis
      • Tolbutamidum

    • secundae generationis
      • Glipizidum

      • Glibenclamidum

      • Glimepiridum

      • Glyburidum



  • Tamoxifenum

  • Fluvastatinum

  • Ketaminum

  • Torasemidum

  • Cannabis



  • Fluconazolum (forte)


  • Acidum valproicum (forte)

  • Amiodaronum

  • Antidepressiva
    • Sertralinum


  • Statini
    • Fluvastatinum

    • Lovastatinum




  • Rifampicinum (forte)


  • Secobarbitalum (forte)

  • Phenobarbitalum


Notae |



  1. ↑ Cojocaru V, Balali-Mood K, Sansom MS, Wade RC (2011). "Structure and dynamics of the membrane-bound cytochrome P450 2C9". PLoS Comput Biol 7 (8): e1002152 


  2. ↑ Cozza KL, Armstrong SC (2001). The Cytochrome P450 System. Drug Interaction Principles for Medical Practice. Washington, DC: American Psychiatric Publishing


  3. ↑ Preskorn SH (1996). Clinical Pharmacology of Selective Serotonin Reuptake Inhibitors. 1st ed.: Professional Communications, Inc.


  4. ↑ Inhibitor cum subtratorum effectibus fortioribus


  5. ↑ Inductor cum subtratorum effectibus minoribus


  6. ↑ Berka K, Hendrychová T, Anzenbacher P, Otyepka M (2011). "Membrane position of ibuprofen agrees with suggested access path entrance to cytochrome P450 2C9 active site". J Phys Chem A 115 (41): 11248-55 



Nexus externi |


  • Descriptio genetica CYP2C9: https://ghr.nlm.nih.gov/gene/CYP2C9#

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