Receptorium dopamini D2 Index Natura physiologica | Notae | Nexus interniTabula navigationis"Dopamine D2S and D2L receptors may differentially contribute to the actions of antipsychotic and psychotic agents in mice"PDSP

Receptoria dopaminiAntipsychotica


scientiaeproteinumcerebroreceptoriumchromosomate 11genicAMPacidis aminicis






Receptorium dopamini D2.


Receptorium dopamini D2 cum scientiae abbreviatura DR2 est proteinum et in cerebro receptorium principale industriarum substantiarum antipsychoticarum. In hominibus in chromosomate 11 (11q23.2) locati geni nomen est DRD2[1]. Nonnullae mutationes adhuc notae sunt.




Index





  • 1 Natura physiologica

    • 1.1 Receptorii dopamini D2 affinitates ligandorum



  • 2 Notae


  • 3 Nexus interni




Natura physiologica |


Post receptorii dopamini D2 stimulationem intra cellulam synthesis cAMP inhibitur. Receptorium dopamini D2 duae formae exstat, altera enim longa, D2L, altera stricta, D2S. Ambae formae geno D2D legunter, sed forma D2L breviori undetriginta acidis aminicis ligamentuculum intracellulare tertium longiore est[2]. Adhuc ligandi utraeque formae non sunt.



Receptorii dopamini D2 affinitates ligandorum |


Exempli sunt:












































Substantia
ligandus
Codex ATCD2
Ki (nM)[3]		D2L
Ki (nM)		D2S
Ki (nM)		Annotatio
HaloperidolumN05AD011.55
MelperonumN05AD03194
NorquetiapinumN05AH04196Norquetiapinum est metabolitus Quetiapini
RisperidonumN05AX083.574.164.73
AmitriptylinumN06AA09196–1,460
NortriptylinumN06AA102,570Nortriptylinum est metabolitus Amitriptylini


Notae |



  1. ↑ Descriptio locus geni DRD2 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=3023


  2. ↑ Xu R, Hranilovic D, Fetsko LA, Bucan M, Wang Y (oct 2002). "Dopamine D2S and D2L receptors may differentially contribute to the actions of antipsychotic and psychotic agents in mice". Mol Psychiatr 7: 1075-82 


  3. ↑ PDSP.


Nexus interni


  • Morbus Parkinson

  • Schizophrenia


-

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